Elsevier's Integrated Pathology

Elsevier's Integrated Pathology

Author: Thomas C. King

ISBN: 9780323043281

Elsevier's Integrated Pathology

1: Cell Injury, Cellular Response… (pages 2-20, 22 images)

Page 2: Time Scale of Reversible and Irreversible Cell Injury
Page 2: Biochemical Alterations In Ischemic Injury
Page 3: Acute Tubular Necrosis In the Kidney
Page 4: Generation, Production, and Detoxification of Oxygen Free Radicals
Page 5: Immune-mediated Injury In the Liver
Page 5: Radiation-induced injury
Page 7: Maintenance of Telomere Length In Different Cell Types
Page 8: Mechanisms of Cellular Adaptation
Page 8: Properties of Labile, Stable, and Permanent Tissues
Page 9: Hypertrophy of Cardiac Myocytes
Page 10: Intracellular Accumulations
Page 10: Intracellular Accumulation of Hemosiderin
Page 11: Squamous Metaplasia at the Transition Zone of the Uterine Cervix
Page 11: Squamous Dysplasia of the Uterine Cervix
Page 12: Nascent Protein Folding and Intracellular Trafficking and Refolding Or Destruction of Denatured Or Abnormal Cellular Proteins
Page 14: Myocytolysis of Cardiac Myocytes, Dystrophic Calcification In the Thyroid Gland, Lipofuscin Pigment In Cardiac Myocytes, and Amyloid Deposition In the Liver
Page 16: Apoptosis Versus Necrosis
Page 17: Intrinsic and Extrinsic Apoptotic Stimuli With Metabolic and Morphologic Changes During Apoptosis
Page 18: Apoptosis In Lymph Node Germinal Center Cells
Page 18: Coagulation Necrosis In a Renal Infarct
Page 19: Gel Electrophoresis Pattern of DNA From Normal, Necrotic, and Apoptotic Cells
Page 20: Ischemic Necrosis of Cardiac Myocytes

2: Inflammation, Inflammatory Med… (pages 22-57, 38 images)

Page 22: Hepatic Congestion
Page 23: Forces Controlling Fluid Flow Across a Vascular Bed and Endothelial Cell Contraction In the Venules Causes Edema
Page 23: Endothelial Cell Activation
Page 24: Inflamed Granulation Tissue
Page 24: Leukocyte Transmigration In Venules and Margination of Granulocytes In an Early Acute Myocardial Infarct
Page 24: Intravascular and Extravascular Inflammatory Cells
Page 25: Early Leukocyte Interactions With Activated Endothelial Cells and Leukocyte Adhesion, Activation, and Transmigration
Page 25: Histology Slides Depicting Acute Inflammation and Bacterial Pneumonia
Page 26: Neutrophil Phagocytosis and Intracellular Killing of Microorganisms
Page 27: Cellular Pathways For Leukocyte Activation
Page 29: Initial Hemostatic Mechanisms In Response To Endothelial Cell Injury
Page 31: Activation of TH1 and TH2 CD4 T cells
Page 31: Maturation Of TH1 And TH2 T Cells And Effector Cytokines As Produced By Mature TH1 And TH2 Cells
Page 32: Activation Of B Cells By Antigen And CD4 T Cells
Page 32: Reactive Germinal Center In A Hyperplastic Tonsil
Page 33: Endothelial And Inducible Nitric Oxide Synthase
Page 34: Arachidonic Acid-Derived Inflammatory Mediators
Page 35: Cyclo-Oxygenase (COX) 1 And 2 Inhibition In Endothelial Cells And Platelets
Page 36: Lipoxin Production Requires Cooperation Between Neutrophils And Platelets
Page 38: Complement Cascade
Page 39: Intrinsic And Extrinsic Coagulation Pathways
Page 40: Coagulation Cascade
Page 40: Role Of Cofactors And Cell Membranes In The Coagulation Cascade
Page 41: Inhibitors of Coagulation
Page 41: Activation of Protein C
Page 42: Role of Endothelial Cells in Modulating Hemostasis
Page 42: Role of Vitamin K–dependent Coagulation Factors and Inhibitors
Page 43: Interactions Between Inflammatory Mediators
Page 45: Types I, II, III, and IV Hypersensitivity
Page 47: Photomicrograph of Abscess
Page 47: Chronic Pyelonephritis
Page 48: Pulmonary Granuloma, Pulmonary Granulomas with Central Necrosis, and Foreign Body Reaction
Page 50: Pathogenesis of Gram-Negative Septic Shock
Page 51: Pathogenesis of Streptococcal Septic Shock
Page 52: Immune-Complex Glomerulonephritis
Page 54: Pathogenesis Of Transplant Rejection
Page 55: Hyperacute and Acute Rejection In A Renal Transplant
Page 57: Aspergillus Infection

3: Tissue Homeostasis, Damage, an… (pages 61-88, 31 images)

Page 61: Changes in the Size of Progenitor Cell Pools Control the Number of Mature Cells Produced
Page 61: Cell Cycle Entry in Different Cell Types
Page 62: G1S Cell Cycle Checkpoint
Page 64: Signal Transduction Mechanisms
Page 64: Covalent Modification of the Angiotensin Receptor (GPCR) in Hypertension
Page 64: Autocrine, Paracrine, and Endocrine Signaling Mechanisms
Page 65: Specialized Signaling Mechanisms
Page 66: Melanin Pigment in the Cytoplasm of Basal Keratinocytes in Skin
Page 68: Anthracotic Pigment in Lung Tissue
Page 70: Herpes Simplex Virus Infection of Esophageal Squamous Mucosa and Cytomegalovirus Infection
Page 71: Vitamin D Metabolism
Page 72: Nonalcoholic Steatohepatitis (NASH)
Page 72: Hormonal Control of Energy Balance and Appetite
Page 73: Spongiosis, Skin with Pitting Edema, and Pulmonary Edema
Page 74: Skin with Petechiae, Skin with Purpura, and Skin with Ecchymoses
Page 75: Virchow's Triad
Page 77: Lines of Zahn
Page 78: Pulmonary Embolus
Page 79: Acute Infarct
Page 79: Healed Renal Infarcts
Page 80: Gangrene
Page 81: Time Scale of Tissue Responses to Injury
Page 81: Consequences of Injury to Permanent and Stable/Labile Cells and the Extracellular Matrix
Page 82: Hepatic Cirrhosis
Page 83: Extracellular Matrix Components, Basement Membrane Zone of the Extracellular Matrix, and Interstitial Zone of the Extracellular Matrix
Page 84: Active Fibrosis and Mature Scar
Page 85: Granulation Tissue
Page 85: Angiogenesis
Page 86: Healing by Primary Intention
Page 87: Healing by Secondary Intention
Page 88: Chronic Ulcer

4: Genetic and Perinatal Disease (pages 91-110, 22 images)

Page 91: Typical Pedigree Showing Autosomal Recessive Inheritance
Page 94: Chloride Conductance in Glandular and Ductal Cells in a Normal Individual and in a Patient with Cystic Fibrosis
Page 95: Normal Cholesterol Metabolism
Page 96: Normal Control of Iron Absorption and Recycling
Page 97: Hemochromatosis of the Liver
Page 98: Typical Pedigree Showing Autosomal Dominant Inheritance
Page 99: Typical Pedigree Showing Sex-linked Recessive Inheritance
Page 100: Dystrophin Gene Deletions in Duchenne's and Becker's Muscular Dystrophy
Page 100: Detection Of Dystrophin Gene Deletions By Multiplex PCR
Page 101: Coagulation Cascade Defects in Hemophilia A and Hemophilia B
Page 101: Typical Pedigree Showing Sex-Linked Dominant Inheritance
Page 104: Balanced Chromosomal Translocations
Page 105: Congenitally Dysplastic Kidney
Page 105: Endocardial Fibroelastosis
Page 106: Hyaline Membranes
Page 107: Intraventricular Hemorrhage
Page 107: Teratoma
Page 108: Hepatoblastoma
Page 108: Common Genetic Alterations in Pediatric Tumors
Page 109: Pathways to Wilms' Tumor Development
Page 109: Wilms' Tumor
Page 110: Wilms' Tumor

5: Neoplasia (pages 112-142, 34 images)

Page 112: Follicular Adenoma of Thyroid Gland
Page 112: Well To Moderately Differentiated Endometrial Adenocarcinoma and Poorly Differentiated Carcinoma
Page 113: Pathways to Tumor Development
Page 114: Distribution of Cancer in Men, Women, and Children
Page 115: Clonal Evolution of Neoplasms
Page 115: Desmoplastic Stromal Reaction
Page 117: Receptor Tyrosine Kinase Signaling in Normal Cells and in Tumor Cells
Page 118: G1S Cell Cycle Checkpoint in Tumor Cells
Page 120: Genetics of Familial and Sporadic Retinoblastoma
Page 121: Microsatellite Instability (MSI) and MSI and Hereditary Nonpolyposis Coli (HNPCC)
Page 122: WNT Signaling Pathway in Normal Cells and in Tumor Cells, Signet Ring Cell Adenocarcinoma and Lobular Carcinoma of the Breast
Page 123: TGF-Beta/SMAD Signaling Pathway
Page 124: Control of Angiogenesis, Hemangioblastoma and Renal Clear-cell Carcinoma
Page 125: Fluorescence In Situ Hybridization (FISH) Showing High-Level HER2/neu Gene Amplification in Breast Cancer Cells and Immunohistochemical Staining For HER2/Neu Protein in Intraductal Breast Cancer
Page 125: Chromosomal Translocations in Tumorigenesis
Page 126: Factors Determining Tumor Phenotype and Squamous Cell Carcinoma
Page 127: Tumor Evolution
Page 127: Relationships Between Key Pathways in Tumorigenesis
Page 128: Viral Carcinogenesis
Page 129: Interactions Between Human Papillomavirus (HPV) Proteins and Components of the G1S Cell Cycle Checkpoint and Dysplastic Cervical Squamous Cells in a Papanicolaou Smear
Page 130: Abnormalities of DNA Repair Pathways that Predispose to Cancer
Page 130: Embryonic Derivation of Different Types of Neoplasms
Page 131: Prostatic Adenocarcinoma, Leiomyosarcoma, Carcinoid Tumor, Oligodendroglioma, Embryonal Rhabdomyosarcoma, and Follicular Lymphoma
Page 132: Invasive and In Situ Carcinoma
Page 133: Dysplasia and Carcinoma Development
Page 133: Low-grade Squamous Dysplasia and High-grade Squamous Dysplasia
Page 134: Adenomatous Polyp of the Colon and Signet Ring Cell Adenocarcinoma of the Colon
Page 135: Mechanisms of Tumor Invasion and Metastasis
Page 136: Different Types of Metastatic Spread
Page 136: Lymph Node Metastasis and Photomicrograph Showing a Dilated Afferent Lymphatic Vessel Connecting with a Draining Lymph Node that is Partially Replaced by Metastatic Tumor
Page 137: Multifocal Metastatic Carcinoma in Lung Tissue
Page 137: Tumor-induced Cachexia
Page 140: PCR Detection of Antigen Receptor Gene Rearrangement in T and B Lymphocytes and Gel Electrophoresis of PCR Products
Page 142: c-Kit Mutations and Gastrointestinal Stromal Tumors

6: Skin and Musculoskeletal Patho… (pages 146-167, 22 images)

Page 146: Spongiotic Dermatitis
Page 147: Lichen Planus
Page 147: Systemic Lupus Erythematosus
Page 148: Psoriasis
Page 149: Pemphigus Vulgaris
Page 150: Verruca Vulgaris
Page 151: Squamous Cell Carcinoma
Page 151: Basal Cell Carcinoma
Page 152: Melanocytic Nevus
Page 152: Malignant Melanoma
Page 154: Osteoarthritis
Page 155: Inflamed Synovium in Rheumatoid Arthritis, Rheumatoid Arthritis with Joint Subluxation, and Rheumatoid Nodule
Page 157: Schematic Diagram of a Long Bone
Page 157: Woven Bone
Page 158: Acute Osteomyelitis
Page 159: Bone Resorption
Page 161: Osteochondroma, Osteosarcoma, Chondrosarcoma, Bone Metastasis, Giant Cell Tumor of Bone, and Paget's Disease of Bone
Page 162: Myositis
Page 163: Rhabdomyosarcoma and Leiomyosarcoma
Page 164: Panniculitis
Page 166: Palmar Fibromatosis
Page 167: Peripheral Neuroectodermal Tumor (PNET)

7: Cardiovascular Pathology (pages 170-195, 22 images)

Page 170: Normal Artery
Page 170: Normal Heart and Heart with Left Ventricular Hypertrophy
Page 171: Hyaline and Hyperplastic Arteriolosclerosis
Page 173: Schematic Illustration of the Development of an Atheroma from a Normal Artery to Mature Plaque
Page 175: Coronary Atherosclerosis, Diagram Showing Plaque Rupture and Resulting Thrombosis in a Complicated Atheroma and Coronary Artery Thrombosis
Page 176: Relationship of Coronary Artery Pathology to Acute Coronary Syndrome (ACS)
Page 177: Myocardial Infarction
Page 178: Serum Cardiac Biomarker Changes Following Acute Myocardial Infarction
Page 183: Classification of Vasculitis by the Size of the Involved Blood Vessels
Page 184: Giant Cell Arteritis-Temporal Artery, Takayasu's Arteritis, and Leukocytoclastic Vasculitis
Page 185: Atherosclerotic Aneurysm
Page 187: Aortic Dissection
Page 188: Pathogenesis of Viral Myocarditis
Page 188: Myocarditis
Page 189: Comparison between Coronary Artery Atherosclerosis and Chronic Graft Rejection
Page 189: Cardiomyopathy
Page 190: Cardiomyopathy
Page 191: Chronology of Events in Rheumatic Heart Disease
Page 192: Rheumatic Endocarditis
Page 192: Endocarditis
Page 194: Congenital Heart Disease
Page 195: Angiosarcoma, Kaposi Sarcoma, and Atrial Myxoma

8: Respiratory Tract and Pleura (pages 198-216, 18 images)

Page 198: Pulmonary Edema and Hemosiderosis
Page 199: Adult Respiratory Distress Syndrome
Page 200: Pneumonia
Page 201: Lung Abscess
Page 202: Calcified Granuloma, Necrotizing Granuloma, and Atypical Mycobacterial Infection
Page 204: Pneumocystic Pneumonia, Coccidiomycosis, and Cytomegalovirus Pneumonia
Page 206: Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease (COPD), and End-stage Lung Disease
Page 207: Asbestos Pneumoconiosis and Pleural Plaques
Page 208: Organizing Pneumonia
Page 209: Sarcoid Granulomas
Page 209: Pulmonary Fibrosis in Scleroderma
Page 210: Pulmonary Emboli and Pulmonary Infarct
Page 211: Cor Pulmonale
Page 212: Bronchogenic Adenocarcinoma, Bronchioalveolar Carcinoma, and Non-small Cell Carcinoma
Page 213: Pulmonary Carcinoid Tumor and Small-cell Undifferentiated Carcinoma
Page 214: Vocal Nodule
Page 215: Laryngeal Papilloma and Squamous Dysplasia in the Larynx
Page 216: Malignant Mesothelioma

9: Gastrointestinal Pathology (pages 219-246, 26 images)

Page 219: Pleomorphic Adenoma and Warthin's Tumor
Page 220: Ruptured Esophageal Varices and Candidal Esophagitis
Page 220: Barret's Esophagus
Page 222: Gastritis
Page 223: Chronic Gastric Ulcer
Page 224: Adenocarcinoma
Page 226: Intestinal Obstruction
Page 226: Colitis
Page 228: Colitis
Page 229: Chronic Inflammatory Bowel Disease
Page 231: Crohn's Disease
Page 232: Colonic Diverticulosis
Page 233: Hyperplastic Polyp, Tubular Adenoma, Villous Adenoma, and Familial Polyposis
Page 234: Colon Cancer Development
Page 235: High-grade Dysplasia in Colonic Mucosa, Colonic Adenocarcinoma, Mucinous Colonic Adenocarcinoma, and Microscopic Section of a Mucinous Adenocarcinoma
Page 236: Carcinoid Tumor
Page 237: Gastrointestinal Stromal Tumor (GIST)
Page 238: Hepatic Cholestasis and Cholelithiasis
Page 239: Sequelae of Viral Hepatitis
Page 239: Chronic Active Viral Hepatitis
Page 242: Nonalcoholic Steatohepatitis (NASH)
Page 243: Hepatic Cirrhosis
Page 244: Hepatic Adenoma
Page 245: Hepatocellular Carcinoma
Page 245: Chronic Pancreatitis
Page 246: Pancreatic Adenocarcinoma

10: Endocrine Pathology (pages 248-260, 13 images)

Page 248: Pituitary Adenocarcinoma
Page 249: Graves' Disease
Page 250: Hashimoto's Thyroiditis
Page 250: Nodular Hypoplasia of the Thyroid
Page 252: Papillary Carcinoma of the Thyroid
Page 253: Medullary Thyroid Carcinoma
Page 254: Parathyroid Adenoma
Page 255: Adrenocortical Adenoma, Adrenal Hemorrhage, and Pheochromocytoma
Page 256: Neuroblastoma
Page 257: Serum Concentration of Glucose and Insulin In Type 1 and Type 2 Diabetes Mellitus
Page 259: Level of Serum Glucose In a Patient With Diabetes Mellitus Treated With Insulin Injections
Page 260: Diabetic Glomerulosclerosis
Page 260: Islet Cell Tumor

11: Hematopoietic Pathology (pages 264-289, 23 images)

Page 264: Schematic Representation of Hematopoiesis From Hematopoietic Pluripotent Stem Cells to Fully Differentiated Cells
Page 266: Anemia of Chronic Disease
Page 268: Idiopathic Thrombocytopenia Purpura (ITP)
Page 268: Thrombotic Thrombocytopenia Purpura (TTP)
Page 269: Acute Myelogenous Leukemia (AML)
Page 271: Philadelphia Chromosome (chromosome 22) and BCR-ABL Fusion Protein Interactions and Effects
Page 272: Extramedullary Hematopoiesis
Page 273: Lymph Node Architecture
Page 275: Toxoplasmosis
Page 277: Chronic Lymphocytic Leukemia (CLL)
Page 278: Follicular Lymphoma
Page 279: Mantle Cell Lymphoma
Page 280: Large-cell, B-cell Lymphoma
Page 280: Burkitt's Lymphoma
Page 282: Acute Lymphocytic Leukemia (ALL)
Page 283: Mycosis Fungoides
Page 284: Reed-Sternberg Cells
Page 285: Nodular Sclerosis Hodgkin's Disease (NSHD)
Page 286: Mixed Cellularity Hodgkin's Disease (MCHD)
Page 287: Multiple Myeloma, Immunohistochemical Stain for CD138, And Serum Protein Electrophoresis
Page 288: Bone Resorption In Multiple Myeloma
Page 288: Marginal Zone Lymphoma
Page 289: Invasive Thymoma

12: Renal and Urinary Tract (pages 292-304, 13 images)

Page 292: Hemorrhagic Cystitis
Page 292: Chronic Pyelonephritis
Page 295: Glomerulonephritis
Page 296: Crescentic Glomerulonephritis And Amyloid Glomerulopathy
Page 297: Hydronephrosis
Page 298: Adult-type Polycystic Kidney Disease
Page 299: Nephrosclerosis
Page 300: Diabetic Glomerulosclerosis
Page 301: End-stage Kidney Disease And Dialysis Kidney
Page 302: Transitional Cell Carcinoma
Page 303: Transitional Cell Carcinoma In Situ
Page 303: Conventional Clear-cell Renal Carcinoma
Page 304: Renal Cell Carcinoma And Renal Oncocytoma

13: Male and Female Genital Tracts… (pages 306-334, 28 images)

Page 306: Testicular Germ Cell Tumor Development
Page 307: Testicular Germ Cell Tumor, Classic Seminoma, Intratubular Germ Cell Neoplasia, Embryonal Carcinoma, and Yolk Sac Tumor
Page 309: Bladder Trabeculation
Page 310: Prostatic Adenocarcinoma
Page 311: Squamous Metaplasia of the Cervical Transformation Zone
Page 312: Squamous Intraepithelial Lesion
Page 313: Squamous Dysplasia and Squamous Cell Carcinoma
Page 314: Lichen Sclerosis And Vaginal Condyloma
Page 315: Clear-cell Carcinoma of the Vagina
Page 316: Endometrial Polyp and Endometriosis
Page 317: Uterine Endometrioid Adenocarcinoma
Page 318: Uterine Leiomyomas
Page 319: Placental Site Trophoblastic Tumor, Hydatidiform Mole And Choriocarcinoma
Page 320: Acute Salpingitis
Page 321: Ovarian Serous Borderline Tumor
Page 322: Epithelial Ovarian Tumor Development
Page 323: Ovarian Papillary Serous Carcinoma
Page 324: Ovarian Granulosa Cell Tumor and Ovarian Brenner Tumor
Page 325: Mature Ovarian Teratoma (dermoid Cyst)
Page 325: Metastatic Adenocarcinoma to the Ovary (Krukenberg's Tumor)
Page 327: Fibrocystic Change - Apocrine Metaplasia, Fibrocystic Change - Sclerosing Adenosis, Myoepithelial Cells, Radial Scar, Usual Type Ductal Hyperplasia, and Atypical Ductal Hyperplasia
Page 329: Intraductal Papilloma And Papillary Carcinoma
Page 329: Fibroadenoma
Page 331: Intraductal Carcinoma, Paget's Disease of Nipple, and Lobular Carcinoma In Situ (LCIS)
Page 332: Infiltrating Ductal Carcinoma (IDC)
Page 333: Infiltrating Lobular Carcinoma (ILC)
Page 334: Breast Cancer
Page 334: Breast Cancer

14: Nervous System (pages 338-353, 15 images)

Page 338: Hydranencephaly, Meningomyelocele, and Anencephaly
Page 339: Perinatal Intraventricular Hemorrhage
Page 340: Cerebral Edema
Page 341: Subarachnoid Hemorrhage
Page 342: Cerebral Infarct
Page 343: Bacterial Meningitis And Microglial Nodule
Page 344: Multiple Sclerosis And Gross Cross-section of Brain Showing Plaques
Page 346: Alzheimer's Disease
Page 347: Epidemiology of Bovine Spongiform Encephalopathy (BSE) and New Variant CJD
Page 348: Parkinson's Disease
Page 350: Astrocytoma, Glioblastoma, and Glioblastoma Multiforme
Page 351: Oligodendroglioma
Page 351: Ependymoma
Page 352: Meningioma
Page 353: Schwannoma And Neurofibroma

© 2005–2025 Elsevier. All rights reserved, including those for text and data mining, AI training, and similar technologies.